To bring the vision of e-Science in Germany to reality, the creation of a robust, flexible and sustainable Grid infrastructure is needed, which consists of network, computing and storage components as well as of Grid services and middleware layers. To reach this goal, a systematic development and organisation of a general middleware and network infrastructure is required. This infrastructure will allow the provision and demanding of Grid resources (i.e. computing power, data, information, programs, etc.) and its dynamic allocation. This infrastructure will build the basis for new community specific applications and will enable new inter disciplinary collaborations to solve scientific problems. On top of this infrastructure new kind of "virtual organisations" will be dynamically created and will benefit from the general availability of services, resources and infrastructures.